Title : Disposition of the cholesterol absorption inhibitor ezetimibe in mdr1a/b (-/-) mice.

Pub. Date : 2007 Dec

PMID : 17828742






2 Functional Relationships(s)
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1 The lipid lowering agent ezetimibe (EZ) and its intestinally formed glucuronide (GLUC) were shown to be substrates of the efflux transporters P-glycoprotein (P-gp) and the multidrug resistance associated protein 2 (MRP2) which markedly influences the disposition and efficacy of EZ in man. Glucuronides ATP binding cassette subfamily B member 1 Homo sapiens
2 The lipid lowering agent ezetimibe (EZ) and its intestinally formed glucuronide (GLUC) were shown to be substrates of the efflux transporters P-glycoprotein (P-gp) and the multidrug resistance associated protein 2 (MRP2) which markedly influences the disposition and efficacy of EZ in man. Glucuronides ATP binding cassette subfamily B member 1 Homo sapiens