Title : Synthetic models related to furanocoumarin-CYP 3A4 interactions. comparison of furanocoumarin, coumarin, and benzofuran dimers as potent inhibitors of CYP3A4 activity.

Pub. Date : 2007 Sep

PMID : 17827777






3 Functional Relationships(s)
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1 comparison of furanocoumarin, coumarin, and benzofuran dimers as potent inhibitors of CYP3A4 activity. benzofuran cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 We prepared a series of furanocoumarin, coumarin, and benzofuran derivatives that have inhibitory effects on the activity of human CYP3A4. benzofuran cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 A synthetic benzofuran dimer, which is more accessible than furanocoumarin dimers, exhibited activity against CYP3A4 comparable to that of furanocoumarin dimers. benzofuran cytochrome P450 family 3 subfamily A member 4 Homo sapiens