Title : EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells.

Pub. Date : 2007 Dec

PMID : 17825525






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 DFMO increased EGFR phosphorylation on tyrosine residues 1173 (pY1173) and 845 (pY845) within 5 min. Eflornithine epidermal growth factor receptor Homo sapiens
2 In addition, inhibition of integrin beta3 activity (with RGDS), Src activity (with PP2), or EGFR kinase activity (with AG1478), increased basal apoptosis and prevented protection conferred by either DFMO or EGF. Eflornithine epidermal growth factor receptor Homo sapiens