Title : Mammalian target of rapamycin inhibition halts the progression of proteinuria in a rat model of reduced renal mass.

Pub. Date : 2007 Oct

PMID : 17804674






2 Functional Relationships(s)
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1 Immunohistochemistry showed that sirolimus attenuated the increased expression of renal vascular endothelial growth factor (VEGF), as well as the expression of VEGF receptors 1 and 2. Sirolimus vascular endothelial growth factor A Rattus norvegicus
2 In conclusion, sirolimus halted the progression of proteinuria and structural damage in a rat model of reduced renal mass, possibly through a reduction in renal VEGF activity. Sirolimus vascular endothelial growth factor A Rattus norvegicus