Pub. Date : 2007 Oct 26
PMID : 17785456
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cellular oligomerization of alpha-synuclein is determined by the interaction of oxidized catechols with a C-terminal sequence. | Catechols | synuclein alpha | Homo sapiens |
| 2 | A critically important modulator of alpha-syn aggregation in vitro is dopamine and other catechols, which can prevent the formation of alpha-syn aggregates in cell-free and cellular model systems. | Catechols | synuclein alpha | Homo sapiens |
| 3 | A critically important modulator of alpha-syn aggregation in vitro is dopamine and other catechols, which can prevent the formation of alpha-syn aggregates in cell-free and cellular model systems. | Catechols | synuclein alpha | Homo sapiens |
| 4 | Despite the profound importance of this interaction for the pathogenesis of PD, the processes by which catechols alter alpha-syn aggregation are unclear. | Catechols | synuclein alpha | Homo sapiens |
| 5 | The data show that the intracellular inhibition of alpha-syn aggregation requires the oxidation of catechols and the specific noncovalent interaction of the oxidized catechols with residues (125)YEMPS(129) in the C-terminal region of the protein. | Catechols | synuclein alpha | Homo sapiens |
| 6 | The data show that the intracellular inhibition of alpha-syn aggregation requires the oxidation of catechols and the specific noncovalent interaction of the oxidized catechols with residues (125)YEMPS(129) in the C-terminal region of the protein. | Catechols | synuclein alpha | Homo sapiens |