Title : Transferrin receptors and selective iron deposition in pancreatic B cells of iron-overloaded rats.

Pub. Date : 1991 Sep

PMID : 1776464






2 Functional Relationships(s)
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1 TfR staining of the islets was weaker in iron-overloaded rats than in the controls. Iron transferrin receptor Rattus norvegicus
2 These findings suggest that 1) iron uptake by islet cells in vivo is regulated and mediated by TfR, 2) intracytoplasmic Ft transforms into stainable iron in iron-overloaded rats, and 3) predominance of TfR expression in B cells may result in selective deposition of iron and predispose B cells to damage and diabetes mellitus in iron-overloaded rats. Iron transferrin receptor Rattus norvegicus