Title : Antitumor effects and drug interactions of the proteasome inhibitor bortezomib (PS341) in gastric cancer cells.

Pub. Date : 2007 Jul

PMID : 17762396






1 Functional Relationships(s)
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1 Bortezomib produced significant growth inhibition in these cells (mean IC50 values: 1.26, 9.44 and 8.63 micromol/l, respectively) and was also observed to decrease the activity of the extracellular signal-regulated kinase 1/2 and Akt signal pathways, increasing the accumulation of p21. Bortezomib mitogen-activated protein kinase 3 Homo sapiens