Title : Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma.

Pub. Date : 2007 Sep 4

PMID : 17720808






1 Functional Relationships(s)
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1 In particular, reciprocal activation of phosphatidylinositol 3-kinases (PI3Ks) and small GTPases like Rac leads to accumulation, at the leading edge, of the PI3K product phosphatidylinositol 3,4,5-trisphosphate (PIP3). phosphatidylinositol 3,4,5-triphosphate thymoma viral proto-oncogene 1 Mus musculus