Pub. Date : 2007 Dec 28
PMID : 17720257
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Repeated amphetamine administration outside the home cage enhances drug-induced Fos expression in rat nucleus accumbens. | Amphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 2 | Induction of the immediate early gene protein product Fos has been used extensively to assess neural activation in the striatum after repeated amphetamine administration to rats in their home cages. | Amphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 3 | We determined the dose-response relationship for amphetamine-induced psychomotor activity and Fos expression in nucleus accumbens and caudate-putamen 1 week after repeated administration of amphetamine or saline in locomotor activity chambers. | Amphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 4 | We determined the dose-response relationship for amphetamine-induced psychomotor activity and Fos expression in nucleus accumbens and caudate-putamen 1 week after repeated administration of amphetamine or saline in locomotor activity chambers. | Amphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 5 | Repeated administration of amphetamine enhanced amphetamine-induced locomotor activity and stereotypy and Fos expression in nucleus accumbens, but not in caudate-putamen. | Amphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 6 | In comparison, levels of Fos expression induced by 1mg/kg amphetamine were not altered in nucleus accumbens or caudate-putamen by repeated amphetamine administration in the home cage. | Amphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 7 | Furthermore, repeated amphetamine administration increased drug-induced Fos expression in enkephalin-positive, but not enkephalin-negative, neurons in nucleus accumbens. | Amphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |