Pub. Date : 2007 Aug
PMID : 17715026
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Effect of phosphorylated c-Jun expression on COX-2 expression in the substantia nigra of MPTP mouse model of subacute Parkinson disease]. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | jun proto-oncogene | Mus musculus |
| 2 | OBJECTIVE: To investigate the effect of phophorylated c-Jun (p-c-Jun) expression on the expression of COX-2 in the substantia nigra (SN) of the MPTP mouse model of subacute Parkinson disease (PD) and explore the possible mechanism of the dopaminergic (DA) neuron death in PD. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | jun proto-oncogene | Mus musculus |
| 3 | OBJECTIVE: To investigate the effect of phophorylated c-Jun (p-c-Jun) expression on the expression of COX-2 in the substantia nigra (SN) of the MPTP mouse model of subacute Parkinson disease (PD) and explore the possible mechanism of the dopaminergic (DA) neuron death in PD. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | jun proto-oncogene | Mus musculus |
| 4 | P-c-Jun was specifically expressed in the nuclei of neurons and p-c-Jun expression level was significantly increased in the SN 6 h after the third injection of MPTP. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | jun proto-oncogene | Mus musculus |
| 5 | P-c-Jun was specifically expressed in the nuclei of neurons and p-c-Jun expression level was significantly increased in the SN 6 h after the third injection of MPTP. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | jun proto-oncogene | Mus musculus |
| 6 | In mice treated with JNK inhibitor, the number of TH-positive neurons and TH expression level in the SN was only decreased by 15% and 20% as compared with the control group (P<0.001) 7 days after the fifth injection of MPTP, COX-2-positive cell number and COX-2 expression level were obviously reduced as compared with the model group (P<0.001), and p-c-Jun was expressed mainly in the cytoplasm of the neurons whose expression level in SN were significantly decreased 6 h after the third injection of MPTP. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | jun proto-oncogene | Mus musculus |
| 7 | CONCLUSION: P-c-Jun expression may play an important role in mediating COX-2 expression in the SN in the MPTP model of subacute PD, and inhibiting p-c-Jun activity may provide neuroprotection to the mouse model. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | jun proto-oncogene | Mus musculus |