Title : Neuroprotective effect of cobalt chloride on hypobaric hypoxia-induced oxidative stress.

Pub. Date : 2008 Feb

PMID : 17706837






2 Functional Relationships(s)
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1 Administration of cobalt appreciably attenuated the RONS generation, oxidation of lipids and proteins and maintained GSH/GSSH ratio similar to that of control cells via induction of HO-1 and MT offering efficient neuroprotection. Cobalt heme oxygenase 1 Rattus norvegicus
2 It can be concluded that cobalt reduces hypoxia oxidative stress by maintaining higher cellular HO-1 and MT levels via hypoxia inducible factor 1alpha (HIF-1alpha) signaling mechanisms. Cobalt heme oxygenase 1 Rattus norvegicus