Title : Nitric oxide selectively depletes macrophages in atherosclerotic plaques via induction of endoplasmic reticulum stress.

Pub. Date : 2007 Oct

PMID : 17700714






1 Functional Relationships(s)
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1 KEY RESULTS: Macrophages and SMCs treated with spermine NONOate or SNAP showed several signs of ER stress, including upregulation of CHOP expression, hyperphosphorylation of eIF2 alpha, inhibition of de novo protein synthesis and splicing of XBP1 mRNA. spermine nitric oxide complex DNA damage inducible transcript 3 Homo sapiens