Title : Enhanced nicotinic receptor function and drug abuse vulnerability.

Pub. Date : 2007 Aug 15

PMID : 17699659






4 Functional Relationships(s)
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1 We found a positive correlation between the response to novelty and nAChR function in each assay conducted, including nAChR modulation of glutamatergic and GABAergic synaptic inputs to VTA dopamine neurons, as well as somatic nAChR responses of VTA neurons. Dopamine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens
2 We found a positive correlation between the response to novelty and nAChR function in each assay conducted, including nAChR modulation of glutamatergic and GABAergic synaptic inputs to VTA dopamine neurons, as well as somatic nAChR responses of VTA neurons. Dopamine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens
3 We found a positive correlation between the response to novelty and nAChR function in each assay conducted, including nAChR modulation of glutamatergic and GABAergic synaptic inputs to VTA dopamine neurons, as well as somatic nAChR responses of VTA neurons. Dopamine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens
4 These findings suggest that differences in nAChR function within the mesoaccumbens dopamine system may contribute to individual differences in drug abuse vulnerability and that these are likely attributable to differences in stress hormone levels. Dopamine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens