Pub. Date : 2007 Oct 5
PMID : 17698848
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ibogaine, a hallucinogenic alkaloid with purported anti-addiction properties, inhibited serotonin transporter (SERT) noncompetitively by decreasing V(max) with little change in the K(m) for serotonin (5-HT). | Ibogaine | solute carrier family 6 member 4 | Homo sapiens |
| 2 | Ibogaine, a hallucinogenic alkaloid with purported anti-addiction properties, inhibited serotonin transporter (SERT) noncompetitively by decreasing V(max) with little change in the K(m) for serotonin (5-HT). | Ibogaine | solute carrier family 6 member 4 | Homo sapiens |
| 3 | Ibogaine also inhibited binding to SERT of the cocaine analog 2beta-2-carbomethoxy-3-(4-[(125)I]iodophenyl)tropane. | Ibogaine | solute carrier family 6 member 4 | Homo sapiens |
| 4 | Ibogaine increased the reactivity of cysteine residues positioned in the proposed cytoplasmic permeation pathway of SERT but not at nearby positions out of that pathway. | Ibogaine | solute carrier family 6 member 4 | Homo sapiens |
| 5 | These results are consistent with the proposal that ibogaine binds to and stabilizes the state of SERT from which 5-HT dissociates to the cytoplasm, in contrast with cocaine, which stabilizes the state that binds extracellular 5-HT. | Ibogaine | solute carrier family 6 member 4 | Homo sapiens |