Title : Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization.

Pub. Date : 2007 Oct 12

PMID : 17698840






2 Functional Relationships(s)
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1 In addition, TRAIL caused increased binding of Bim and Puma to Mcl-1 that was inhibited by IETD(OMe)-fmk but not SP600125. bim MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 Collectively, these observations not only suggest a model in which Mcl-1 confers TRAIL resistance by serving as a buffer for Bak, Bim, and Puma, but also identify sorafenib as a potential modulator of TRAIL sensitivity. bim MCL1 apoptosis regulator, BCL2 family member Homo sapiens