Pub. Date : 2007 Nov
PMID : 17683485
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Peroxisome proliferator-activated receptor-alpha is required for the neurotrophic effect of oleic acid in neurons. | Oleic Acid | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 2 | As oleic acid has been reported to be a ligand and activator of the peroxisome proliferator-activated receptor (PPAR), we focus on this family of receptors. | Oleic Acid | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 3 | As oleic acid has been reported to be a ligand and activator of the peroxisome proliferator-activated receptor (PPAR), we focus on this family of receptors. | Oleic Acid | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 4 | Consequently, we investigated the involvement of PPARalpha (Nr1c1) in oleic acid-induced neuronal differentiation. | Oleic Acid | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 5 | Consequently, we investigated the involvement of PPARalpha (Nr1c1) in oleic acid-induced neuronal differentiation. | Oleic Acid | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 6 | Our results indicate that oleic acid activates PPARalpha in neurons. | Oleic Acid | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 7 | In addition, the effect of oleic acid on neuronal morphology, growth-associated protein 43 and microtubule-associated protein 2 expression decreases in neurons after PPARalpha has been silenced by small interfering RNA. | Oleic Acid | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 8 | Taken together, our results suggest that PPARalpha could be the receptor for oleic acid in neurons, further broadening the range of functions attributed to this family of transcription factors. | Oleic Acid | peroxisome proliferator activated receptor alpha | Homo sapiens |