Pub. Date : 2007 Aug
PMID : 17683383
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Relationship between Kaposi"s varicelliform eruption in Japanese patients with atopic dermatitis treated with tacrolimus ointment and genetic polymorphisms in the IL-18 gene promoter region. | Tacrolimus | interleukin 18 | Homo sapiens |
| 2 | IL-18 gene promoter polymorphisms were analyzed in 21 AD patients treated with tacrolimus ointment and in 100 healthy volunteers. | Tacrolimus | interleukin 18 | Homo sapiens |
| 3 | Six AD patients with Kaposi"s varicelliform eruption during the treatment with tacrolimus ointment showed significantly higher frequency in G-to-C mutations at the IL-18 gene promoter region -137 compared with 15 AD patients without Kaposi"s varicelliform eruption. | Tacrolimus | interleukin 18 | Homo sapiens |
| 4 | These results suggest that the onset of Kaposi"s varicelliform eruption following the treatment with tacrolimus ointment is associated with the mutation of G-to-C in the IL-18 gene promoter region -137, and that caution is required when using tacrolimus ointment for treating AD patients with this mutation. | Tacrolimus | interleukin 18 | Homo sapiens |
| 5 | These results suggest that the onset of Kaposi"s varicelliform eruption following the treatment with tacrolimus ointment is associated with the mutation of G-to-C in the IL-18 gene promoter region -137, and that caution is required when using tacrolimus ointment for treating AD patients with this mutation. | Tacrolimus | interleukin 18 | Homo sapiens |