Pub. Date : 2007 Sep 21
PMID : 17662692
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We provide evidence that the proteasome-inhibitors Bortezomib and MLN273 are both substrates of MDR-1 by using knockdown of MDR-1 via a transposon-based vector system stably expressing siRNA against MDR-1 in MDR-1-overexpressing K562/Dox cells. | Bortezomib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | We provide evidence that the proteasome-inhibitors Bortezomib and MLN273 are both substrates of MDR-1 by using knockdown of MDR-1 via a transposon-based vector system stably expressing siRNA against MDR-1 in MDR-1-overexpressing K562/Dox cells. | Bortezomib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | We provide evidence that the proteasome-inhibitors Bortezomib and MLN273 are both substrates of MDR-1 by using knockdown of MDR-1 via a transposon-based vector system stably expressing siRNA against MDR-1 in MDR-1-overexpressing K562/Dox cells. | Bortezomib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | We provide evidence that the proteasome-inhibitors Bortezomib and MLN273 are both substrates of MDR-1 by using knockdown of MDR-1 via a transposon-based vector system stably expressing siRNA against MDR-1 in MDR-1-overexpressing K562/Dox cells. | Bortezomib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Our report provides evidence that MLN273 and, to a lesser degree, Bortezomib are both MDR-1-substrates, which might be relevant for drug-resistance in cancer. | Bortezomib | ATP binding cassette subfamily B member 1 | Homo sapiens |