Title : A pivotal role for Mcl-1 in Bortezomib-induced apoptosis.

Pub. Date : 2008 Jan 31

PMID : 17653083






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Our results show that Bortezomib, but not doxorubicin or melphalan, triggers Mcl-1 cleavage in Mcl-1(wt/wt), but not Mcl-1(Delta/null) MEFs and induces sub-G(1) phase cells; caspase-3 and -9, and PARP cleavage as well as morphological signs of apoptosis. Bortezomib poly(ADP-ribose) polymerase 1 Homo sapiens