Title : Nitric oxide donor upregulation of stromal cell-derived factor-1/chemokine (CXC motif) receptor 4 enhances bone marrow stromal cell migration into ischemic brain after stroke.

Pub. Date : 2007 Nov

PMID : 17641243






3 Functional Relationships(s)
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1 We tested the hypothesis that a nitric oxide donor, DETA-NONOate, increases endogenous ischemic brain SDF1 and BMSC CXCR4 and MMP9 expression, which promotes BMSC migration into ischemic brain and thereby enhances functional outcome after stroke. 2,2'-(hydroxynitrosohydrazono)bis-ethanamine matrix metallopeptidase 9 Homo sapiens
2 DETA-NONOate significantly increased BMSC CXCR4 and MMP9 expression and promoted BMSC adhesion and migration to MBECs and astrocytes compared with nontreatment BMSCs. 2,2'-(hydroxynitrosohydrazono)bis-ethanamine matrix metallopeptidase 9 Homo sapiens
3 Inhibition of CXCR4 or MMPs in BMSCs significantly decreased DETA-NONOate-induced BMSC adhesion and migration. 2,2'-(hydroxynitrosohydrazono)bis-ethanamine matrix metallopeptidase 9 Homo sapiens