Title : Oxidative conversion of 6-fluorobenzo(c)phenanthrene to its K-region oxide by liver microsomes from 3-methylcholanthrene treated rats: reversal of stereoselectivity of cytochrome P-450c due to the influence of fluoro group.

Pub. Date : 1991 Dec 31

PMID : 1764102






1 Functional Relationships(s)
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1 Interestingly, the microsomal cytochrome P-450c forms predominantly the 5R,6S enantiomer from B(c)Ph, while it exhibits a reversal of stereoselectivity with 6-fluorobenzo(c)phenanthrene forming predominantly the 7S,8R enantiomer. 5r,6s cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus