Pub. Date : 2007 Sep 14
PMID : 17635921
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine-induced AMPK phosphorylation appeared to be mediated by reactive oxygen species based on the finding that nicotine significantly increased superoxide anions and 3-nitrotyrosine-positive proteins, exogenous peroxynitrite (ONOO(-)) mimicked the effects of nicotine on AMPK, and N-acetylcysteine (NAC) abolished nicotine-enhanced AMPK phosphorylation. | onoo | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 2 | Inhibition of AMPK using either pharmacologic (insulin, compound C) or genetic means (overexpression of dominant negative AMPK; AMPK-DN) abolished FAS inhibition induced by nicotine or ONOO(-). | onoo | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 3 | Inhibition of AMPK using either pharmacologic (insulin, compound C) or genetic means (overexpression of dominant negative AMPK; AMPK-DN) abolished FAS inhibition induced by nicotine or ONOO(-). | onoo | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 4 | Inhibition of AMPK using either pharmacologic (insulin, compound C) or genetic means (overexpression of dominant negative AMPK; AMPK-DN) abolished FAS inhibition induced by nicotine or ONOO(-). | onoo | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |