Title : Ouabain stimulates protein kinase B (Akt) phosphorylation in opossum kidney proximal tubule cells through an ERK-dependent pathway.

Pub. Date : 2007 Sep

PMID : 17634416






2 Functional Relationships(s)
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1 In an in vitro kinase assay, active recombinant ERK phosphorylated recombinant Akt on Ser(473). Serine EPH receptor B2 Homo sapiens
2 These findings suggest that ouabain-stimulated ERK phosphorylation is required for Akt phosphorylation on Ser(473), cell proliferation, and stimulation of Na(+)/K(+)-ATPase-mediated (86)Rb uptake in OK cells. Serine EPH receptor B2 Homo sapiens