Pub. Date : 2007 Aug 8
PMID : 17627277
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PKA-induced resistance to tamoxifen is associated with an altered orientation of ERalpha towards co-activator SRC-1. | Tamoxifen | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 2 | Now, we demonstrate that phosphorylation of S305 in ERalpha by PKA leads to an altered orientation between ERalpha and its coactivator SRC-1, which renders the transcription complex active in the presence of tamoxifen. | Tamoxifen | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |