Pub. Date : 2007 Jul
PMID : 17620218
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Of six cDNA-expressed human P450 enzymes tested, CYP2B6 and CYP1A2, followed by CYP3A4, had high catalytic activities at a 20 microM propofol concentration, corresponding to clinical plasma levels. | Propofol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | In a panel of individual human liver microsomes, propofol omega- and 4-hydroxylation activities (at the substrate concentration of 20 microM) were highly correlated with CYP2B6 contents, and moderately with CYP3A4 contents. | Propofol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | These results suggest that CYP2B6 has an important role in propofol omega- and 4-hydroxylation in human livers and that the hepatic contents of CYP2B6, CYP3A4, and CYP1A2 determine which P450 enzymes play major roles in propofol oxidation in individual humans. | Propofol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |