Title : Methylglyoxal suppresses TNF-alpha-induced NF-kappaB activation by inhibiting NF-kappaB DNA-binding.

Pub. Date : 2007 Aug 15

PMID : 17617381






1 Functional Relationships(s)
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1 We show that the conserved Cys 38 residue, which is located in the DNA binding loop of NF-kappaB p65 and responsible for the redox regulation of the transcription factor, is involved in the methylglyoxal-mediated inhibition of p65 DNA-binding. Cysteine nuclear factor kappa B subunit 1 Homo sapiens