Title : Development of a pharmacokinetic model to optimize the dosage regimen of TS-1, a combination preparation of tegafur, gimeracil and oteracil potassium.

Pub. Date : 2007 Jun

PMID : 17603216






2 Functional Relationships(s)
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1 UFT is a combination preparation of tegafur with uracil, which also inhibits DPD, though less potently; UFT has a higher content of tegafur than that in TS-1. Uracil dihydropyrimidine dehydrogenase Homo sapiens
2 METHODS: We developed a model incorporating the inhibition of DPD by gimeracil and uracil, and fitted the model to the observed kinetics of tegafur and 5-FU after the administration of TS-1 and UFT. Uracil dihydropyrimidine dehydrogenase Homo sapiens