Title : Desmethyl derivatives of indomethacin and sulindac as probes for cyclooxygenase-dependent biology.

Pub. Date : 2007 Jul 20

PMID : 17602619






1 Functional Relationships(s)
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1 2"-Desmethyl derivatives of indomethacin and sulindac sulfide were synthesized that demonstrated reduced COX inhibitory activity but were inducers of peroxisome proliferator-activated receptor gamma-dependent transcription, adipocyte differentiation, or apoptosis of colon cancer cell lines. sulindac sulfide peroxisome proliferator activated receptor gamma Mus musculus