Pub. Date : 2007 Sep
PMID : 17596313
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gag influences transformation by Abelson murine leukemia virus and suppresses nuclear localization of the v-Abl protein. | Glycosaminoglycans | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | Although the Gag-derived myristoylation signal targets the v-Abl protein to the plasma membrane, the protein contains the entire MA and p12 sequences and a small number of CA-derived residues. | Glycosaminoglycans | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 3 | Although all of the mutant proteins retained kinase activity, those defective in transformation were reduced in their ability to activate Erk, suggesting a role for Gag sequences in v-Abl signaling. | Glycosaminoglycans | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 4 | Immunofluorescence analysis revealed that a v-Abl protein retaining only the first 34 amino acids of Gag localized to the nucleus. | Glycosaminoglycans | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 5 | These data indicate that Gag sequences are important for normal v-Abl signaling and that they suppress nuclear localization of the molecule. | Glycosaminoglycans | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |