Title : Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.

Pub. Date : 2007 Jul 26

PMID : 17585748






1 Functional Relationships(s)
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1 Structure-activity studies have revealed that substitutions, particularly hydrophilic groups in the pyridine 5-position, differentially modulate the agonist activity at ganglionic vs central nAChR subtypes, so that improved subtype selectivity can be demonstrated in vitro. pyridine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens