Title : Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices.

Pub. Date : 2007 Sep

PMID : 17578901






1 Functional Relationships(s)
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1 Inhibition of renal uptake (via OAT3) and efflux processes (via MRP2 and MRP4) explains the possible sites of drug-drug interaction for methotrexate with probenecid and some NSAIDs, including their glucuronides. Probenecid ATP binding cassette subfamily C member 4 Homo sapiens