Title : Ligand binding to cytochrome P450 3A4 in phospholipid bilayer nanodiscs: the effect of model membranes.

Pub. Date : 2007 Sep 28

PMID : 17573349






2 Functional Relationships(s)
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1 We explore the energetics of four ligands (6-(p-toluidino)-2-naphthalenesulfonic acid (TNS), alpha-naphthoflavone (ANF), miconazole, and bromocriptine) binding to CYP3A4 incorporated into Nanodiscs. alpha-naphthoflavone cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 The dissociation constants for binding to the active site in CYP3A4-Nanodiscs were 4.0 microm for TNS, 5.8 microm for ANF, 0.45 microm for miconazole, and 0.45 microm for bromocriptine. alpha-naphthoflavone cytochrome P450 family 3 subfamily A member 4 Homo sapiens