Title : Uncoupling protein-2 up-regulation and enhanced cyanide toxicity are mediated by PPARalpha activation and oxidative stress.

Pub. Date : 2007 Aug 15

PMID : 17573087






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Wy14,643 produced a concentration- and time-dependent up-regulation of UCP-2 that was linked to enhanced cyanide-induced cell death. Cyanides uncoupling protein 2 Homo sapiens
2 It was concluded that a PPARalpha-mediated pathway and an oxidative stress pathway independent of PPARalpha mediate the up-regulation of UCP-2 and subsequent increased vulnerability to cyanide-induced cytotoxicity. Cyanides uncoupling protein 2 Homo sapiens