Title : Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA.

Pub. Date : 2007 Jul

PMID : 17570247






1 Functional Relationships(s)
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1 These experiments demonstrated that CYP1A1, CYP1B1, and CYP3A4 are able to oxidize catechol estrogens to their respective quinones, which can further react with GSH, protein, and DNA, the last resulting in depurinating adducts that can lead to mutagenesis. catechol cytochrome P450 family 1 subfamily A member 1 Homo sapiens