Pub. Date : 2007 Aug
PMID : 17566751
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this report, we studied the regulation of tPA activity in vivo during ageing in normal mice and in a mouse model of AD characterized by an exacerbated endogenous Abeta accumulation. | Tetradecanoylphorbol Acetate | amyloid beta (A4) precursor protein | Mus musculus |
| 2 | We observed that cerebral tPA activity was decreased during ageing in normal mice and that this effect was worsened in mice overproducing Abeta peptides. | Tetradecanoylphorbol Acetate | amyloid beta (A4) precursor protein | Mus musculus |
| 3 | A similar study in sporadic AD and age-matched control brain tissues revealed that the tPA proteolytic activity was negatively correlated to Abeta peptides levels supporting the data observed in mice. | Tetradecanoylphorbol Acetate | amyloid beta (A4) precursor protein | Mus musculus |