Title : Noxa up-regulation and Mcl-1 cleavage are associated to apoptosis induction by bortezomib in multiple myeloma.

Pub. Date : 2007 Jun 1

PMID : 17545623






1 Functional Relationships(s)
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1 Thus, in myeloma cells, the mechanistic basis for bortezomib sensitivity can be explained mainly by the model in which the sensitizer Noxa can displace Bim, a BH3-only activator, from Mcl-1, thus leading to Bax/Bak activation. bim phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens