Title : Functional imaging of multidrug resistance in an orthotopic model of osteosarcoma using 99mTc-sestamibi.

Pub. Date : 2007 Nov

PMID : 17541583






2 Functional Relationships(s)
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1 PURPOSE: The purpose of this work was the development of an orthotopic model of osteosarcoma based on luciferase-expressing tumour cells for the in vivo imaging of multidrug resistance (MDR) with (99m)Tc-sestamibi. Technetium Tc 99m Sestamibi ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus
2 The kinetic analysis of (99m)Tc-sestamibi washout provides information on the functional activity of MDR related to P-glycoprotein expression and its pharmacological inhibition in osteosarcoma. Technetium Tc 99m Sestamibi ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus