Title : COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity.

Pub. Date : 2007 Sep

PMID : 17539917






5 Functional Relationships(s)
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1 Recent studies show that endogenous cannabinoid 2-arachidonoylglycerol (2-AG) is a natural substrate for COX-2, and it can be oxygenated by COX-2 to form prostaglandin glyceryl esters. glyceryl 2-arachidonate prostaglandin-endoperoxide synthase 2 Homo sapiens
2 Recent studies show that endogenous cannabinoid 2-arachidonoylglycerol (2-AG) is a natural substrate for COX-2, and it can be oxygenated by COX-2 to form prostaglandin glyceryl esters. glyceryl 2-arachidonate prostaglandin-endoperoxide synthase 2 Homo sapiens
3 Recent studies show that endogenous cannabinoid 2-arachidonoylglycerol (2-AG) is a natural substrate for COX-2, and it can be oxygenated by COX-2 to form prostaglandin glyceryl esters. glyceryl 2-arachidonate prostaglandin-endoperoxide synthase 2 Homo sapiens
4 Recent studies show that endogenous cannabinoid 2-arachidonoylglycerol (2-AG) is a natural substrate for COX-2, and it can be oxygenated by COX-2 to form prostaglandin glyceryl esters. glyceryl 2-arachidonate prostaglandin-endoperoxide synthase 2 Homo sapiens
5 In this study, we demonstrate that prostaglandin E(2) glyceryl ester (PGE(2)-G), a major COX-2 oxidative metabolite of 2-arachidonoylglycerol, enhanced hippocampal glutamatergic synaptic transmission indicated by the increased frequency of miniature excitatory post-synaptic currents, and induced neuronal injury/death revealed by the terminal transferase dUTP nick end labeling staining and caspase 3 activation. glyceryl 2-arachidonate prostaglandin-endoperoxide synthase 2 Homo sapiens