Title : Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway.

Pub. Date : 2007 Sep 15

PMID : 17537996






2 Functional Relationships(s)
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1 Combination of ATO and dexamethasone resulted in increased Bad and rapid down-regulation of XIAP, while levels of the antiapoptotic regulator Mcl-1 remained unchanged. Arsenic Trioxide X-linked inhibitor of apoptosis Homo sapiens
2 Expression of dominant-active Akt, reduction of Bad expression by RNA interference, or overexpression of XIAP abrogated the sensitizing effect of ATO. Arsenic Trioxide X-linked inhibitor of apoptosis Homo sapiens