Title : The induced prostaglandin E2 pathway is a key regulator of the respiratory response to infection and hypoxia in neonates.

Pub. Date : 2007 Jun 5

PMID : 17535900






3 Functional Relationships(s)
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1 To determine the mechanism by which IL-1beta depresses respiration, we examined a prostaglandin E(2) (PGE(2))-dependent pathway in newborn mice and human neonates. Dinoprostone interleukin 1 beta Mus musculus
2 To determine the mechanism by which IL-1beta depresses respiration, we examined a prostaglandin E(2) (PGE(2))-dependent pathway in newborn mice and human neonates. Dinoprostone interleukin 1 beta Mus musculus
3 We conclude that IL-1beta adversely affects breathing and its control by mPGES-1 activation and PGE(2) binding to brainstem EP3 receptors, resulting in increased apnea frequency and hypoxia-induced mortality. Dinoprostone interleukin 1 beta Mus musculus