PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17535900-2 2007 To determine the mechanism by which IL-1beta depresses respiration, we examined a prostaglandin E(2) (PGE(2))-dependent pathway in newborn mice and human neonates. Dinoprostone 82-100 interleukin 1 beta Mus musculus 36-44 17535900-2 2007 To determine the mechanism by which IL-1beta depresses respiration, we examined a prostaglandin E(2) (PGE(2))-dependent pathway in newborn mice and human neonates. Dinoprostone 102-108 interleukin 1 beta Mus musculus 36-44 17535900-8 2007 We conclude that IL-1beta adversely affects breathing and its control by mPGES-1 activation and PGE(2) binding to brainstem EP3 receptors, resulting in increased apnea frequency and hypoxia-induced mortality. Dinoprostone 96-102 interleukin 1 beta Mus musculus 17-25