Pub. Date : 2007 Jun 15
PMID : 17530733
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mitomycin-DNA adducts induce p53-dependent and p53-independent cell death pathways. | Mitomycin | tumor protein p53 | Homo sapiens |
| 2 | Mitomycin-DNA adducts induce p53-dependent and p53-independent cell death pathways. | Mitomycin | tumor protein p53 | Homo sapiens |
| 3 | In cell lines lacking wild-type p53, DMC was reproducibly more cytotoxic than MC, but it generated barely detectable signal transduction markers associated with apoptotic death. | Mitomycin | tumor protein p53 | Homo sapiens |
| 4 | In cell lines with a functional p53 pathway, both MC and DMC induced apoptosis. | Mitomycin | tumor protein p53 | Homo sapiens |
| 5 | In the presence of p53, both MC and DMC activate procaspases; however, the spectrum of procaspases involved differs for the two drugs, as does induction of p73. | Mitomycin | tumor protein p53 | Homo sapiens |