PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17530733-0 2007 Mitomycin-DNA adducts induce p53-dependent and p53-independent cell death pathways. Mitomycin 0-9 tumor protein p53 Homo sapiens 29-32 17530733-0 2007 Mitomycin-DNA adducts induce p53-dependent and p53-independent cell death pathways. Mitomycin 0-9 tumor protein p53 Homo sapiens 47-50 17530733-5 2007 In cell lines lacking wild-type p53, DMC was reproducibly more cytotoxic than MC, but it generated barely detectable signal transduction markers associated with apoptotic death. Mitomycin 38-40 tumor protein p53 Homo sapiens 32-35 17530733-8 2007 In cell lines with a functional p53 pathway, both MC and DMC induced apoptosis. Mitomycin 50-52 tumor protein p53 Homo sapiens 32-35 17530733-9 2007 In the presence of p53, both MC and DMC activate procaspases; however, the spectrum of procaspases involved differs for the two drugs, as does induction of p73. Mitomycin 29-31 tumor protein p53 Homo sapiens 19-22