Title : Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells.

Pub. Date : 2007 Oct 1

PMID : 17525289






2 Functional Relationships(s)
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1 Treatment with thapsigargin and tunicamycin led to the activation of all 3 branches of the UPR, with early splicing of XBP1 indicative of IRE1 activation, upregulation of CHOP consistent with ER resident kinase (PERK) activation, and activating transcription factor 6 (ATF6) splicing. Tunicamycin activating transcription factor 6 Homo sapiens
2 Treatment with thapsigargin and tunicamycin led to the activation of all 3 branches of the UPR, with early splicing of XBP1 indicative of IRE1 activation, upregulation of CHOP consistent with ER resident kinase (PERK) activation, and activating transcription factor 6 (ATF6) splicing. Tunicamycin activating transcription factor 6 Homo sapiens