Title : Nicotine protects kidney from renal ischemia/reperfusion injury through the cholinergic anti-inflammatory pathway.

Pub. Date : 2007 May 23

PMID : 17520028






2 Functional Relationships(s)
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1 Nicotine pretreatment protected mice from renal dysfunction in a dose-dependent manner and through the alpha7nAChR, as attested by the absence of protection in alpha7nAChR-deficient mice. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 All together, these data highlight that nicotine exerts a protective anti-inflammatory effect during kidney I/R through the cholinergic alpha7nAChR pathway. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus