Title : Cisplatin cytotoxicity of auditory cells requires secretions of proinflammatory cytokines via activation of ERK and NF-kappaB.

Pub. Date : 2007 Sep

PMID : 17516123






2 Functional Relationships(s)
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1 We also observed a significant increase in the protein and mRNA levels of proinflammatory cytokines in both serum and cochleae of cisplatin-injected rats, which was suppressed by intraperitoneal injection of etanercept, an inhibitor of TNF-alpha. Cisplatin tumor necrosis factor Rattus norvegicus
2 Immunohistochemical studies revealed that TNF-alpha expression was mainly located in the spiral ligament, spiral limbus, and the organ of Corti in the cochleae of cisplatin-injected rats. Cisplatin tumor necrosis factor Rattus norvegicus