Title : Novel engineered trastuzumab conformational epitopes demonstrate in vitro and in vivo antitumor properties against HER-2/neu.

Pub. Date : 2007 Jun 1

PMID : 17513761






2 Functional Relationships(s)
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1 The three-dimensional structure of human HER-2 in complex with trastuzumab reveals that the Ag-binding region of HER-2 spans residues 563-626 that comprises an extensive disulfide-bonding pattern. Disulfides erb-b2 receptor tyrosine kinase 2 Homo sapiens
2 The three-dimensional structure of human HER-2 in complex with trastuzumab reveals that the Ag-binding region of HER-2 spans residues 563-626 that comprises an extensive disulfide-bonding pattern. Disulfides erb-b2 receptor tyrosine kinase 2 Homo sapiens