Pub. Date : 2007 Sep
PMID : 17505786
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Apoptosis by cisplatin requires p53 mediated p38alpha MAPK activation through ROS generation. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | Using the HCT116 colon carcinoma derived cell line we have established that the apoptotic activity of cisplatin requires the onset of a p53-mediated p38alpha MAPK pathway through generation of reactive oxygen species (ROS). | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | In addition, we have identified p38alpha as the isoform necessary for cisplatin-induced apoptosis, upon activation by p53-mediated ROS production. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 4 | We conclude that the p53/ROS/p38alpha MAPK cascade is essential for cisplatin-induced cell death in HCT116 cells and the subsequent p38alpha/p53 positive feedback loop strongly enhances the initial p53 activation. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 5 | We conclude that the p53/ROS/p38alpha MAPK cascade is essential for cisplatin-induced cell death in HCT116 cells and the subsequent p38alpha/p53 positive feedback loop strongly enhances the initial p53 activation. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |