Pub. Date : 2007 May 15
PMID : 17494760
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation. | Tyrosine | tyrosine kinase non receptor 2 | Homo sapiens |
| 2 | Ack1 knockdown inhibited heregulin-dependent AR tyrosine phosphorylation, AR reporter activity, androgen-stimulated gene expression, and AR recruitment. | Tyrosine | tyrosine kinase non receptor 2 | Homo sapiens |
| 3 | In 8 of 18 primary androgen-independent prostate tumor samples, tyrosine-phosphorylated AR protein was detected and correlated with the detection of tyrosine-phosphorylated Ack1. | Tyrosine | tyrosine kinase non receptor 2 | Homo sapiens |
| 4 | In 8 of 18 primary androgen-independent prostate tumor samples, tyrosine-phosphorylated AR protein was detected and correlated with the detection of tyrosine-phosphorylated Ack1. | Tyrosine | tyrosine kinase non receptor 2 | Homo sapiens |
| 5 | Activated Ack1 phosphorylated AR protein at Tyr-267 and Tyr-363, both located within the transactivation domain. | Tyrosine | tyrosine kinase non receptor 2 | Homo sapiens |
| 6 | Activated Ack1 phosphorylated AR protein at Tyr-267 and Tyr-363, both located within the transactivation domain. | Tyrosine | tyrosine kinase non receptor 2 | Homo sapiens |
| 7 | Mutation of Tyr-267 completely abrogated and mutation of Tyr-363 reduced Ack1-induced AR reporter activation and recruitment of AR to the androgen-responsive enhancer. | Tyrosine | tyrosine kinase non receptor 2 | Homo sapiens |
| 8 | Mutation of Tyr-267 completely abrogated and mutation of Tyr-363 reduced Ack1-induced AR reporter activation and recruitment of AR to the androgen-responsive enhancer. | Tyrosine | tyrosine kinase non receptor 2 | Homo sapiens |