Pub. Date : 2007 Jun
PMID : 17487428
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we present data demonstrating that the active metabolite of vitamin D, 1alpha,25-dihydroxy-vitamin D3, is a PARP inhibitor. | Calcitriol | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 2 | UV irradiation-mediated PARP activation in human keratinocytes can be inhibited by treatment with vitamin D, 7-dehydrocholesterol or 1alpha,25-dihydroxyvitamin D3. | Calcitriol | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 3 | Inhibition of cytochrome P450 reversed the PARP inhibitory action of vitamin D and 7-dehydrocholesterol, indicating that conversion to 1alpha,25-dihydroxyvitamin D3 mediates their PARP inhibitory action. | Calcitriol | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 4 | Inhibition of cytochrome P450 reversed the PARP inhibitory action of vitamin D and 7-dehydrocholesterol, indicating that conversion to 1alpha,25-dihydroxyvitamin D3 mediates their PARP inhibitory action. | Calcitriol | poly(ADP-ribose) polymerase 1 | Homo sapiens |